Yeon Joo Kim, Kang Pa Lee, Do Young Lee, Yun Tae Kim, Dongsoo Koh, Yoongho Lim, Myeong Sik Yoon
Abstract
Chalcones are hydrophobic polyphenols with extremely poor aqueous solubility. In this study, we prepared a new chalcone derivative-loaded nanoparticle (DPP-23-loaded NP) using a monomethoxy poly(ethylene glycol)-poly(D,L-lactide) copolymer which, in an aqueous environment, spontaneously forms a micellar formation with an average particle size of 20.8 nm. Exposure to various concentrations of DPP-23-loaded NP significantly diminished the cell viability of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner. Our data show that DPP-23-loaded NP is a reliable drug delivery system, as observed by the fluorescein isothiocyanate (FITC) intensity accumulation in MDA-MB-231 cells.
Yeon Joo Kim, Kang Pa Lee, Do Young Lee, Yun Tae Kim, Dongsoo Koh, Yoongho Lim, Myeong Sik Yoon
Abstract
Chalcones are hydrophobic polyphenols with extremely poor aqueous solubility. In this study, we prepared a new chalcone derivative-loaded nanoparticle (DPP-23-loaded NP) using a monomethoxy poly(ethylene glycol)-poly(D,L-lactide) copolymer which, in an aqueous environment, spontaneously forms a micellar formation with an average particle size of 20.8 nm. Exposure to various concentrations of DPP-23-loaded NP significantly diminished the cell viability of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner. Our data show that DPP-23-loaded NP is a reliable drug delivery system, as observed by the fluorescein isothiocyanate (FITC) intensity accumulation in MDA-MB-231 cells.