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상호명: UMUST R&D
대표: 이강파
Address: 서울 도봉구 마들로 13길 61 창동 씨드큐브 C동 303호
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Do Young Lee 1 , Kang Pa Lee 2 , Suji Baek 3 , Ji Su Park 4 , Young Jin Kim 5 , Kilnam Kim 6 , Song-Rae Kim 7 , Myeong Sik Yoon 8
Abstract
Chalcones are hydrophobic polyphenols with poor aqueous solubility. In this study, we prepared a new aspirin-conjugated chalcone derivative-loaded nanoparticle (AS-DK143-loaded NP) using mPEG-PLA co-polymer which, in an aqueous environment, spontaneously forms a micellar formulation with an average particle size of 22.55 nm. Exposure to varying concentrations of AS-DK143 NP significantly diminished the cell viability of 4T1 cells in a concentration-dependent manner. In tumor regression and biodistribution studies in 4T1-luc cell bearing mice, AS-DK143 NPs were shown to selectively target cancer cells and significantly reduce tumor size. These properties suggest anti-cancer efficacy, combined with low toxicity to healthy tissues, indicating a potential role as a safer alternative to currently available chemotherapy agents.